Brain Development fMRI Analysis
HCP Development Study — Developmental neuroscience analysis
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Specification Curve Analysis
Methods & Documentation
Paper 1: Developmental Age Effects (Ages 5–21)
Paper 2: Age and Puberty Effects (Ages 8–17)
About
Analysis of brain development during adolescence using task-based fMRI data from the HCP Development Study (n ≈ 1,000 participants, ages 5–21).
Study Design
Participants completed a monetary reward guessing task during fMRI scanning. We model BOLD responses to feedback (win vs. loss) across brain networks, tracing how reward circuitry matures from childhood through late adolescence.
Analysis Pipeline
| Paper | Age Range | Key Predictors | Models |
|---|---|---|---|
| Paper 1 | 5–21 | Age (linear + GAM) | m_null, m_age_linear, m_age |
| Paper 2 | 8–17 | Age + Puberty | 6 models incl. interactions |
Methods Summary
- GAMs — Flexible modeling of non-linear developmental trajectories via
mgcv - Network-Level Analysis — Results organized by 12 Glasser atlas networks
- Specification Curve Analysis — Robustness across 8 covariate sets × weighting choices
- Reproducible — Fully automated SLURM pipeline on Harvard FASRC cluster